- Original Article
- Morphological Study of Cardiotoxicity in Adriamycin Treated Rats.
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H W Shin, J Y Kim, C U Joo, P H Hwang, J S Kim
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Clin Exp Pediatr. 1989;32(8):1117-1222. Published online August 31, 1989
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This experiment was carried out to investigate the morphological changes of cardiac tissue in
Adriamycin treated rats.
Adriamycin was administered (2.5 mg/kg/wk) for 5 weeks, subcutaneously. Cardiac tissue stained
by H-E and Trichrom’s method.
Clinical findings of congestive heart failure were also observed during experiment.
The results were as follows ;
1) Symptoms and signs of congestive heart failure (tachypnea, ascites, hepatomegaly) were
appeared in 43% (6 out... |
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